Purpose: To report a case of a 46-year-old patient affected by polypoidal choroidal vasculopathy (PCV) in large colloid drusen (LCD) and to show how switching to intravitreal injection of aflibercept could be considered as a useful treatment of PCV not responsive to other anti-vascular endothelial growth factor (VEGF) injections.Observations: A nautica voyage hajuvesi 46-year-old woman was referred to our department with diagnosis of early-onset retinal drusen.Multimodal imaging confirmed the diagnosis of LCD in both eyes, complicated by suggestive PVC in the left eye.Due to the absence of anatomical improvement after 6 intravitreal injections of ranibizumab, the patient was switched and treated by a single injection of aflibercept, showing gymnastics wall decals a complete anatomical and functional recovery.
Conclusions and Importance: This case suggests progressive development of PCV as a possible late evolution of degenerating LCD.In case of exudative complication, intravitreal aflibercept injection could be considered as a useful treatment, especially in patients who are not responsive to others anti-VEGF injections.